Estimation of Serum bilirubin and other biochemical parameters in patients with fatty liver disease

Background/Goals: Serum bilirubin has cytoprotective and antioxidant properties. Furthermore, a lower risk of cardiovascular and metabolic disorders is linked to higher serum bilirubin levels. Few studies, meanwhile, have examined the potential link between blood bilirubin as well as NAFLD, or Fatty liver disease without alcohol consumption, which is strongly linked to additional.metabolic conditions. Clarifying the relationship between serum total bilirubin levels and NAFLD was the goal of this investigation.
Methods: A cross-sectional study was carried out on 17,348 participants who were getting regular checkups. Participants with a history of hepatitis or who tested positive for the hepatitis B or hepatitis C viruses were not included. Normal ultrasound findings and a daily alcohol consumption of less than 20 g were used to diagnose NAFLD.
Results: 9,076 (52.3%) of the subjects were men, and their average age was 49. In both men and women, As blood bilirubin levels increased, the prevalence of NAFLD gradually decreased (P<0.001 for both). Blood bilirubin levels and the prevalence of NAFLD were found to be negatively correlated by multivariate regression research that controlled for other metabolic risk factors [odds ratio (OR)=0.88, 95% confidence interval (CI)=0.80-0.97]. Additionally, NAFLD and serum total bilirubin levels were inversely/dose-dependently related (OR=0.83, 95% CI=0.75-0.93 in the third quartile; OR=0.80, 95% CI=0.71-0.90 in the fourth quartile vs. lowest quartile, P for trend <0.001).
Conclusions: The prevalence of NAFLD was found to be inversely correlated with serum bilirubin levels, regardless of recognized metabolic risk factors. For NAFLD, serum bilirubin may serve as a protective indicator.